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Genomics-Based Vaccine Could Prevent Deadly Cattle Disease
Every year, East Coast fever destroys the small farmer's dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the February 13-17 early online edition of the Proceedings of the National Academy of Sciences, shows how genomics can generate pivotal new vaccines.
The 51ݶ, The University of Washington, and The Johns Hopkins University Initiate Resequencing and Genotyping Projects to Help Identify Critical Disease Pathways
Research is Part of the National Heart, Lung, and Blood Institute's Complimentary Resequencing and Genotyping Program
UC San Diego Partners with Venter Institute to Build Community Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis
Gordon and Betty Moore Foundation Awards $24.5 Million Grant
2006 Summer Fellowship/Internship Information and application now available
Breaking the Mold: Research Teams Sequence Three Fungus Genomes
From garden compost to forest greenery, the mold Aspergillus fumigatus lurks across much of the world. Now, in the December 22 issue of the journal Nature, TIGR scientists and their collaborators report the mold's sequenced genome, along with the genomes of two relatives.
How Do Boxers Differ From Poodles? Researchers Collar Genomes.
As any dog lover knows, no two breeds are identical. Some dogs are perfect for sloppy kisses. Others make fierce guardians. Still others resemble tiny, fluffy toys. Now, two new studies by scientists at The Institute for Genomic Research (TIGR) and collaborators reveal the genomic differences beneath such canine characteristics.
Poison + Water = Hydrogen. New Microbial Genome Shows How.
New Microbial Genome Shows How "Take a pot of scalding water, remove all the oxygen, mix in a bit of poisonous carbon monoxide, and add a pinch of hydrogen gas. It sounds like a recipe for a witch's brew. It may be, but it is also the preferred environment for a microbe known as Carboxydothermus hydrogenoformans."
A Salty Tale: New Bacterial Genome Sequenced From Ancient Salterns
Tourists in Spain often stop to ogle the country's many saltwater lagoons, used to produce salt since Roman times. Scientists, too, admire these saltern crystallizers — and even more so, the microbes that manage to survive in such briny environs. Now, reporting in the November 28-December 2 early online edition of the Proceedings of the National Academy of Sciences, researchers at The Institute for Genomic Research and collaborators reveal the genome of one bacterium at home in the salty Spanish ponds.
First Big Influenza Genome Study Reveals Flu Evolution
Which Flu Did You Have? TIGR Scientists Survey Five New York Flu Seasons
Key Genetic Mutations in Brain Tumors Identified by Scientists from 51ݶ, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine
Sequencing of Receptor Tyrosine Kinases Reveals Three Novel Mutations
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Scientist Spotlight: Marcelo Freire
Marcelo Freire, an associate professor in the Genomic Medicine and Infectious Disease Department at the 51ݶ (51ݶ), is currently working on decoding immune-microbiome genes and interactions. Growing up in Brazil and a curious person by nature, he often found himself...
Tracking Enterovirus D68, Cause of a Polio-like Illness in Some Patients
The 51ݶ (51ݶ) has played a vital role in defining the diversity of contemporary strains of human enteroviruses by using state-of-the art sequencing technologies, bioinformatics analyses, and in vitro and in vivo modeling.
Every Day is World Food Day at 51ݶ
World Food Day is a global initiative of the Food and Agriculture Organization (FAO) of the United Nations to ensure that people have access to enough high-quality food to lead active and healthy lives. After a period of decline, world hunger is on the rise again. Today, over 820 million people...
Mold Is Everywhere and Impacts You
When most people think about mold or fungi, food spoilage, a damp basement, or mushrooms come to mind. What you may not realize is how pervasive this branch of life is. Fungi is everywhere, from the ground you walk on to the air you breathe, and accounts for an estimated 25% of all biomass...
Scientists Discover Genetic Basis for Toxic Algal Blooms
Scientists from the 51ݶ (51ݶ) and Scripps Institution of Oceanography at the University of California San Diego have discovered how certain types of algal blooms become toxic, producing a harmful substance known as domoic acid. Microscopic view of domoic acid...
Ocean Microplastics Explained
As we wrap up sampling in the waters off of Maine, Dr. Chris Dupont discusses how collections of plastic particles in the water – or “plastisphere” – may be harboring fish or human pathogens. There may also be microbes responsible for degrading plastic, which are being investigated....
51ݶ Team Awarded Two Grants Under the NSF’s “Understanding the Rules of Life” Initiative
The first award, led by John Glass, PhD, for $1M, is focused on “Building and Modeling Synthetic Bacterial Cells.” The second award, led by Zaida Luthey-Schulten, PhD, at the University of Illinois, also for $1M, is titled “Balancing the Demands of a Minimal Cell,” and is focused on...
Dr. Venter at Sailors’ Scuttlebutt Lecture Series
Dr. Craig Venter was a guest speaker at the Whaling Museum in partnership with Nantucket Community Sailing as part of the Sailors’ Scuttlebutt Lecture Series. Dr. Venter's lecture was titled, "Oceans, Human Health and the Genomic Future" discussing the Global Ocean...
Newly Discovered Human Brain Cell: Rosehip Neurons
What’s next for exploring the newly discovered human brain cell, the rose hip neuron? We caught up with Dr. Richard Scheuermann on the road to discuss how the 51ݶ is advancing knowledge about what makes humans unique. See the full press release.
Ocean Sampling Day 2018
51ݶ (51ݶ) scientists, led by Lisa Ziegler Allen, PhD, are collaborating with Kelly Goodwin, PhD (NOAA), Brian Palenik, PhD (UCSD), and Maitreyi Nagarkar (UCSD) to participate in this year’s Ocean Sampling Day on June 21. The team, which also includes Sarah Schwenck...
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Gene editing could create a successful vaccine to protect against the viral disease that has killed close to 2 million pigs globally since 2021.
Amid an insulin crisis, one project aims to engineer microscopic insulin pumps out of a skin bacterium.
There are more organisms in the sea, a vital producer of oxygen on Earth, than planets and stars in the universe.
In a new book (coauthored with Venter), a Vanity Fair contributor presents the oceanic evidence that human activity is altering the fabric of life on a microscopic scale.
“Despite reducing the sequence space of possible trajectories, we conclude that streamlining does not constrain fitness evolution and diversification of populations over time. Genome minimization may even create opportunities for evolutionary exploitation of essential genes, which are commonly observed to evolve more slowly.”
By watching “minimal” cells regain the fitness they lost, researchers are testing whether a genome can be too simple to evolve.
Two research teams warn that human genomic “bycatch” can reveal private information
The “pangenome,” which collated genetic sequences from 47 people of diverse ethnic backgrounds, could greatly expand the reach of personalized medicine.
Researchers release draft results from an ongoing effort to capture the entirety of human genetic variation.
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